Drug treatment of hyperlipidemia marine

Propylene Glycol Alginate, sodium alginate molecules in the hydroxyl and carboxyl groups were introduced on the sulfonyl and propylene glycol base made of marine drug treatment of hyperlipidemia. This product is light yellow amorphous powder; odorless, slightly sweet taste; have cited wet. Soluble in water, in ethanol, acetone or aether.
Inspection
Acidity of this product 0.1g, 10ml water dissolved, according to the determination (China Pharmacopoeia 1990 Edition 2 Appendix 44), pH value of 5.0 ~ 7.0.
Color of the solution of this product 0.1g, 10ml water dissolved, the solution color with yellow 3 standard color solution (Chinese Pharmacopoeia 1990 edition of the first two methods in Appendix 57) to compare, not deeper.
Intrinsic viscosity of this product about 3g (calculated by dry goods), accurately weighed, set 100ml volumetric flask, add sodium chloride solution (0.7mol / L) to the mark, shake well, with a dry melt down 3 glass funnel vacuum filtration, the filtrate was discarded early, precise amount of filtrate added 10ml, according to the determination (China Pharmacopoeia 1990 Edition 2 Appendix 19), intrinsic viscosity should be 9.0 to 14.0.
Chloride to take this product 0.2g, dissolved in 20ml water, add nitric acid 4ml, filtration, the filtrate is divided into halves, split 50ml colorimetric tube, a silver nitrate test solution add 1ml, shake, place 10 minutes, as was cloudy, repeated filtration, the filtrate to clarify, diluted with water to 40ml, coupled with the standard sodium chloride solution, 5.0ml and the amount of water to make 50ml, shake, stand for 5 minutes in the dark, as the control solution.
Another add water to make 40ml, plus 1ml of silver nitrate test solution with the amount of water to make into a 50ml, shake, in the dark for 5 minutes, compared with the control solution, not thicker (0.05%).
Sulfate to take this product 4.0g, add water 15ml, dissolved, add ethanol to 45ml, and the test solution with sodium hydroxide to neutral, add ethanol to make into a 50ml, shaken, centrifuged (3000 rev / min ) 10 minutes, the supernatant 5ml, diluted with water to 50ml, shake, take diluent 2.5ml (oral use) or 10.0ml (injection), according to inspection (China Pharmacopoeia 1990 Edition 2 Appendix 48), such as occurrence of turbidity, with standard potassium sulfate solution, 1.0ml liquid made of more control, not thicker (0.5% oral; injection of 0.125%).
Drying of this product, vacuum drying at 80 ℃ for 4 hours, not less than 10.0% weight loss.
Heavy metals to take this product 1.0g, according to inspection (China Pharmacopoeia 1990 Edition 2 Appendix 51 second method), not containing heavy metals over twenty millionths.
Arsenic take this product 1.0g, add nitric acid 0.5ml, evaporated, let cool, add sulfuric acid 1ml, slowly burn to completely carbonized, set 500 ~ 600 ℃ burn, let cool, add hydrochloric acid dissolved in 5ml and 23ml water , according to inspection (Chinese Pharmacopoeia 1990 edition of the first two methods in Appendix 53) shall comply with the provisions of (0.0002%).